|
KMID : 1161420100130061490
|
|
Journal of Medicinal Food
2010 Volume.13 No. 6 p.1490 ~ p.1493
|
|
|
Hemodialysis Alters Lipid Profiles, Total Antioxidant Capacity, and Vitamins A, E, and C Concentrations in Humans
|
|
Montazerifar Farzaneh
Hashemi Mohammad
Karajibani Mansour
Dikshit Madhurima
|
|
|
Abstract
|
|
|
|
Although hemodialysis (HD) is essential for end-stage renal disease patients, at the same time it causes oxidative stress and long-term pro-atherosclerotic effects. This study aimed to determine lipid profile as well as the total antioxidant capacity (TAC) and vitamins A, E, and C in HD patients. The study enrolled 31 patients (50.3?±?14.9 years old) undergoing maintenance 4-hour HD three times per week with a polysulfone membrane dialyzer for a mean of 76.1 months (range, 7?120 months) and 31 healthy individuals (47.8?±?13.9 years old). Lipid profiles were determined spectrophotometrically using commercially available kits. Total antioxidant capacity was determined by ferric reducing/antioxidant power assay, levels of vitamins A and E were assayed using high-pressure liquid chromatography, and the level of vitamin C was measured by a photometric method. Our results showed that before HD, the levels of TAC and vitamin A were significantly higher than in normal subjects, whereas the levels of high-density lipoprotein (HDL) and vitamin C were lower than in control subjects (P??.05). After HD, the levels of HDL-cholesterol, vitamins E and C, and TAC decreased significantly (P?
|
|
|
KEYWORD
|
|
|
hemodialysis, lipid profile, nonenzymatic antioxidants, total antioxidant capacity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|